Cyclooxygenase-2 and the treatment of cholangiocarcinoma
10.3760/cma.j.issn.1673-4203.2009.01.019
- VernacularTitle:环氧合酶-2与胆管癌治疗的相关研究及进展
- Author:
Hui LIU
;
Ping XUE
- Publication Type:Journal Article
- Keywords:
eyclooxygenase-2;
cholangiocarcinoma;
treatment
- From:
International Journal of Surgery
2009;36(1):48-51
- CountryChina
- Language:Chinese
-
Abstract:
Cyclooxygenase (COX) is a crucial enzyme in the biosynthesis of prostaglandins.There are two COX isoforrns:COX-1 and COX-2.Recently it is demonstrated that there is a close relationship of COX-2 with the occurrence,development and metabasis of tumor; COX-2 inhibitor is hoping to be a new target in tumor therapy.The article overviews many progresses of COX-2 about its expression,modulation and mecha-nism of carcinogenesis in cholangiocarcinoma in order to explore the prospect of the COX-2 inhibitors in cholangioearcinoma treatment.
