Clinical study of acute/subacute interstitial pneumonia in patients with dermatomyositis
10.3760/cma.j.issn.1673-4904.2009.01.008
- VernacularTitle:皮肌炎合并急性/亚急性间质性肺炎临床研究
- Author:
Xuebing FENG
;
Huayong ZHANG
;
Bingzhu HUA
- Publication Type:Journal Article
- Keywords:
Dermammyesitis;
Acute/subacute interstitial pneumonia;
Survival rate
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(1):17-20
- CountryChina
- Language:Chinese
-
Abstract:
objecive To chrify clinical characteristics and outcme of acute/subacute interstitial pneumonia(A/SIP)in patients with dermatomyositis.Methods The elinical data of 10 dermatemyositis patients accompanied with A/SIP who hospitalized in April 2006 to April 2008 were reviewed.Data of 9 dermatomyesitis patients with non-A/SIP interstitial lung diseases treated during the same period were also documented for the comparison.The survival rate of patients wag statistically analyzed.Results Compared with those dermatomyositis patients with non-A/SIP interstitial lung diseases,patients with A/SIP had shorter disease courses and higher incidences of fever,heliotrope rash and ground glass opacity in CT image(P＜0.01or＜0.05).However,the levels of serum creatine kinase tended to be normal.After following up 6 months,only 1 patientwithA/SIP survived(P=0.0001).Logistic regression analysis showed the combination treatment of hormonal,cyclophosphamide and cyclosparine might prolong the survival time(P=0.107).Conclusions A/SIP with dermatomyositis is a fatal disease which needs to be early diagnosed and treated.Patients having dyspnea or breathless in the early stage,especially those with recurrent fever,heliotrope rash and normal serum creatine kinase is predicted to develop A/SIP later.A better outcome may be achieved when treating the patients with stemids plus cyclophosphamide and cyclosporine.
