Effect of glucocorticoid by oral medication or intrathoracic injection on the expression of IL-6,IL-8 and sIL-2R in serum and pleural fluid in patients of tuberculous pleurisy
10.3760/cma.j.issn.1673-4904.2009.01.012
- VernacularTitle:口服及胸腔注射糖皮质激素对结核性胸膜炎患者血清和胸腔积液中IL-6、IL-8和sIL-2R表达水平的影响
- Author:
Rong GUO
;
Meihua GAO
;
Cunzhi LIN
;
Yong LI
;
Min CHEN
- Publication Type:Journal Article
- Keywords:
Tuberculosis,pleura;
Glucocorticoids;
Interleukin-6;
Interhukin-8;
Recepter,interleukin-2
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(1):30-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of gheocorticoid by oral medication or intrathoracic iniection on the expression of IL-6,IL-8 and sIL-2R in gerum and pleural fluid in patients of tuberculous pleurisy.Methods Twenty tuberculous pleurisy patients were treated with ghcocortieoid by oral medication (oral group)and 20 cases by intrathoracic injection(injection group).ELISA wag employed to detect the levels of IL-6,IL-8 and sIL-2R in serum and pleural fluid before treatment and 3,6 and 9 days after treatment.Results The levels of serum IL-6 and IL-8 decreased and sIL-2R increased obviously in injection group at 3,6 and 9 days after treatment(P＜0.01).Meanwhile the levels of IL-6 and IL-8 in pleural fluid decreased and sIL-2R increased obviously(P＜0.01).The levels of IL-6 and IL-8 were significantly lower and the levels of aIL-2R were significantly higher in injection group than those in oral group(P＜0.01).One month after treatment,the rate of complete absorpion of pleural fluid was higher in injection group(80%)than thatin oral group(45%),the rate of pachynsis pleurae was lower in injection group(10%)than that in oral group(40%),P＜0.05.Conclusions Intrathoracic injection of ghcocorticoid shows stronger suppression of cellular immune function in cavum pleurae and weaker suppression of the general immune sysmm than oral medication.Intrathoracic injection of glucocorticoid can increase the therapeutic effect and decrease side effect in tuberculous pleurisy.
