The effect of hypothermia on the early inflammatory reaction in acute lung injury induced by intestinal ischemia-reperfusion in rabbits
10.3760/cma.j.issn.1671-0282.2009.01.014
- VernacularTitle:低温对肠缺血-再灌注所致急性肺损伤早期炎症反应的影响
- Author:
Guangjun PENG
;
Lu LIANG
;
Jun XU
;
Guohui CAO
;
Xinping WANG
;
Hongwei YE
;
Xuemei JIA
;
Xuezhong YU
- Publication Type:Journal Article
- Keywords:
Intestinal ischemia-reperfusion;
Acute lung injury;
Mild hypothermia;
Moderate hypothermia;
Inflammatory reaction
- From:
Chinese Journal of Emergency Medicine
2009;18(1):51-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of hypothemah on the early inflammatory reaction in acute lung injury induced by intestinal ischemia-repeffusion(IlR)in rabbits.Method Seventy-two healthy rabbits provided by Peking Union Medical Colege Hospital Anhnal center were randomly divided into four groups(n=18 pergroup):(1)normothermia control group (rectal temperature 37-38 C;sham group);(2)normothermia IlR group(rectal temperature 37-38 C);(3)mild hypothermia HR group(rectal temperature 32-35℃);and (4)moderate hypothermia IIR group(rectal temperature 28-31.9C).Acute lung injury was induced by claIllp.ithe superiornteric artery(SMA)for 1 hour and declamping the SMA for 6 hours.Hypothermia WaS induced by surface cooling.Before and 2.4 and 6 hours after IIR,the Olasmlevels o,IL-,IL-6 and IL10 were measured.All rabbits were killed 6 hours after IIR and water content in lung tissue Wttk'assessed.Iaght mieropic examination was performed tbr morphological assessment of the hmg.The data were analyzed by AN()VA.Statistical significance wag dned as a P of<0.05.Results In the IIR groups,the plasma levels ofTHE-a.IL-l,IL-6 and IL-10 and lung water were increased.There Was evidence of acute lung injury from morphologi-cal assessment of the lung.The acute lung injury induced by IIR was improved by hypethennia.Mild hypothermia Was similar to moderate hypothermia for the treatment of acute lung injury induced by IIR.ConclusiotMild hy-pothermia and moderate hypothermia Can significantly improve acute lung injury induced by IIR in rabbits.Mild hypothea had similar efficacy to moderate hypothermia for the treatment of acute lung injury induced by IIR.
