Association of polymorphism 1188A/C of interlenkin-12B gene with multiple sclerosis
10.3760/cma.j.issn.1006-7876.2009.01.005
- VernacularTitle:白细胞介素12亚单位p40基因1188A/C多态与多发性硬化的关系
- Author:
Meng LIU
;
Xueqiang HU
;
Bin ZHANG
;
Yuge WANG
;
Yu YANG
;
Zhengqi LU
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Interleukin-12 subunit p40;
Polymorphism,restriction fragmentlength;
Polymerase chain reaction
- From:
Chinese Journal of Neurology
2009;42(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the asseciation of 1188A/C polyrnorphism of Interlenkin-12B gene (IL-12B) with remit-relapse multiple sclerosis (RRMS) in the southern Chinese population.Methods Ninety-four patients with RRMS and 145 age- and-sex-matched normal controls were recnfited in this study.The polymorphism was detected by using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) assay in these subjects.The frequencies of the alleles in each group were statistically analyzed.Results The frequency of the allele A increased significantly in RRMS patients (64.4%) compared with that in healthy controls (53.8%, χ2=5.228, P=0.022).An increased risk for MS was suggested in carriers of the A allele (OR=1.551, 95% CI=1.064-2.262).Conclusions The A allele in 1188A/C polymorphism of IL-12B gene may be a risk factor for RRMS in southern Chinese population.
