Studies on the pathogenesis of Balo' s concentric sclerosis with magnetic resonance imaging and diffusion-weighted imaging

VernacularTitle:Balo同心圆性硬化磁共振成像与弥散加权成像特点及其机制
Author: Feng CHEN ; Tao LIU ; Jianjun LI ; Chuanzi LI
Publication Type:Journal Article
Keywords: Diffuse cerebral sclerosis of Schilder; Magnetic resonance imaging; Diffusionmagnetic resonance imaging
From: Chinese Journal of Neurology 2009;42(1):25-29
CountryChina
Language:Chinese
Abstract: Objective To sum up the magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) characters in patients with concentric sclerosis, and to investigate the association between imaging and possible pathogenesis.Methods Three patients with clinically diagnosed concentric sclerosis underwent MR] and DWI, one of whom was additionally performed 1H-magnetic resonance spectroscopy imaging (1H-MRS).Results Multiple lesions of laminated demyelination alternating with spared white matter were demonstrated in all 3 patients, and the enhanced lesions appeared to be concentric coils.Rings of alternating hypointense and hyperintense layers were shown on the DWI image, with apparent diffusion coefficient alternating correspondingly to the layers of the histologically demyetinated and undemyelinated areas.Conclusions Balo' s concentric sclerosis has unique characteristics on MRI and DWI, which corresponds to changes in its pathology and provides evidence for a better understanding of its pathophysiologic mechanisms.