Expression of NM-23,PCNA,p53 and S-100 in colorectal carcinoma in the elderly and their relationship
10.3760/cma.j.issn.1673-4203.2009.01.010
- VernacularTitle:NNM-23、PCNA、p53、S-100在高龄大肠癌中的表达和相关性研究
- Author:
Xiaojuan DENG
;
Huizhen ZHANG
;
Zhigang WANG
;
Zhe YANG
;
Qi ZHENG
- Publication Type:Journal Article
- Keywords:
elderly;
eoloreetal carcinoma;
NM-23;
PCNA;
p53;
S-100;
immunohistoehemistry
- From:
International Journal of Surgery
2009;36(1):24-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of NM-23 ,PCNA,p53 and S-100 in colorectal cancer tissues and their relationship.Methods Three hundred and seventy eases of elderly eolorectal cancer were labelled with NM-23,PCNA,p53 and S-100 and staged by pTNM classification.Results The positive rates of NM-23,PCNA,p53 and S-100 were 74.9% ,60.3% ,58.1% ,68.1% respectively.In elderly group,the expression of NM-23 had a neg-ative correlation with that of PCNA (r = -0.101 ,P = 0.026).However the expression of NM-23 had a positive corre-lation with that of p53 (r =0.111 ,P =0.016 ),the expression of S-100 had a positive correlation with that of p53 (r=0.112,P = 0.015 ),the expression of S-100 had a positive correlation with that of PCNA (r =-0.229,P =0.000).Conclusions In the elderly patients,NM-23,p53 and S-100 were significantly correlated with the inva-sion,metastasis and prognosis of eoloreetal cancer.PCNA may be a stimulative factor in the invasion and metastasis of colorectal cancer.NM-23 ,PCNA,p53 and S-100 can serve as effective markers in reflecting the invasion,metas-tasis and prognosis of colorectal carcinoma in the elderly.
