Effects of different means of liquid recucitation on mirrocircultation in rats with hemorrhagic shock
10.3760/cma.j.issn.1671-0282.2009.02.012
- VernacularTitle:不同液体复苏对失血性休克大鼠微循环的影响
- Author:
Changjiu YU
;
Ertian WANG
;
Jum ZHANG
;
Zehui TAN
;
Min SHU
;
Lin CHEN
- Publication Type:Journal Article
- Keywords:
Shock;
Hemorrhagic;
Liquid resuscitation;
Renal cortex;
Microcirculation kidney
- From:
Chinese Journal of Emergency Medicine
2009;18(2):158-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different means of liquid resuscitation on microcirculation in rats with hemorrhagic shock. Method A model of rats with hemorrhagic shock was established in 40 Wistar rats. The rats were randomly divided into 4 groups according on different means of liquid resuscitation, and killed 24 hours after the examination, group A: without liquid resuscitation; group B: low-molecular-weight-40; group C: 7.5% hypertonic saline,group D:low-molecular-weight-40 + hyperonic saline. As well as the microcirculation in kidney was observed using electron microscope. Results In group without resuscitation, the microcirculation in kidney damaged severely; While in group with hypertonic or low molecule dextran alone, there was harm with dif-ferent degrees, and the microcirculation in kidney was nearly perfect in group with both hypertonic and low molecule dextran alone. Conclusions Different means of liquid resuscitation may infect the microcirculation in kidney, which with both hypertonic and low molecule dextran can protect the microcirculation in kidney.
