The expression and significance of PAI-1,t-PA,u-PA and u-PAR in induced sputum in patients with asthma
10.3760/cma.j.issn.1673-4904.2009.01.001
- VernacularTitle:PAI-1、t-PA、u-PA、u-PAR 在支气管哮喘患者诱导痰中的表达及意义
- Author:
Qiudi ZHANG
;
Jianan HUANG
- Publication Type:Journal Article
- Keywords:
Asthma;
Tissue plasminogen activator,Urinary plasminogen activator;
Plasminogen activator inhibitor-1
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(1):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the levels of plasminogen activator inhibitor(PAI)-1,tissue plasminogen activator(t-PA),urokinase-type plasminogen activator(u-PA)and urokinase-type plasminogen activator receptor(u-PAR)in induced sputum in patients with asthma and analyze their clinical significances in pathogenesis of asthlna.Methods The induced sputum was isolated from 15 normal subjects(control group),29 patients with acute attack of asthma(attack group)and 26 stable asthma patients(stable group).The levels of PAl-1,t-PA,u-PA and u-PAR were measured by ELISA.Meanwhile FEV1%pred of all groups were evaluated.Results The levels of PAI-1 and u-PAR of induced sputum were significandy higher in at-tack group[(23.32±21.64),(0.766±0.272)μg/L]and stable group[(17.23±9.40),(0.700±0.271)μg/L]than those in control group[(5.99±5.04),(0.516±0.197)μg/L](P＜0.05).As for the induced sputum concentrations of u-PA and t-PA,there were no significant differences among the attack group[(0.287±0.235),(7.68±3.46)μg/L],stable group[(0.251±0.276),(9.88±4.68)μg/L]and control group[(0.239±0.322),(10.35±7.47)μg/L].In stable group,the level of PAI-1 had a negative correlation with the FEV1%pred(r=-0.756,P＜0.01).In stable group,the level of PAI-1 had a positive correlation with the length of disease course(r=0.454,P＜0.05).Conclusion PAI-1 and u-PAR maybe involved in pathophysiologic change of asthma.
