Diltiazem in combination with metoprolol for treating aortic dissection

VernacularTitle:地尔硫卓联合大剂量美托洛尔治疗主动脉夹层
Author: Junming LI ; Jing JING ; Xiaoguang LIU ; Wenjun FU ; Xinjie HUANG ; Jin REN ; Zhilin ZHU ; Chao YUAN ; Aihua ZUO
Publication Type:Journal Article
Keywords: Aortic dissection; Metoprolol; Diltiazem; Heart rate; Blood pressure
From: Chinese Journal of Emergency Medicine 2009;18(2):198-200
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical therapeutic effects of intravenous infusion of dihiazem in com-bination with metoprolol for treating aortic dissection. Method From June 2005 to January 2008, fourteen patients with aortic dissection (male 8, female 4) in the First Hospital of Yichang,were treated with diltiazen 1～5 μg/(kgrate 30 min,60 min, 120 min,6 h, 1 d and 7 d after treatment were recorded. All data were analyzed using self-matching t test. Results The heart rate reduced significantly 60 min after treatment. The heart rate reduced (21±5) beats/min from the baseline. The total effective rate was 100% .The blood pressure reduced significantly 30min after treatment. The systolic pressure reduced to (126.2±11.1 ) mmHg and diastolic pressure declined to (80.3±8.1) mmHg. No severe cardiac side-effect observed. Conclusions Dihiazem in combination with meto-prolol can reduce heart rate and blood pressure markedly and safely in aortic dissection patients.