Clinical study of plasma(1→3)-β-D-glucan in invasive fungal infections

VernacularTitle:血浆(1→3)-β-D-葡聚糖检测诊断侵袭性真菌感染的临床研究
Author: Fang LIU ; Li WANG ; Shuyang XU ; Yunzhuo CHU
Publication Type:Journal Article
Keywords: Glucan endo-1,3-beta-D-glucosidass; Candida; Diagnostic test,mutine; Invasive fungal infections
From: Chinese Journal of Postgraduates of Medicine 2009;32(1):20-23
CountryChina
Language:Chinese
Abstract: Objective To study the clinical significance of plasma(1→3)-β-D-Oaten measurement in invasive fungal infections.Methods The levels of plasma(1→3)-β-D-glucan were measured bymicrobiology kinetic rapid reader MB-80 and GKT-5M set dymmic fungus detecting kit in 14 patients proven to suffer from invasive fungal infection and 13 healthIy voluntary persons.And the difference between them was compared.Results In 14 patients with invasive fungal infection,8 patients had fungal infection of lower respiratory tract and lung,6 patients had fungemia.There were 11 patients infected by monilia(1 patient combined infection),2 patients infected by aspergillus,and 2 patients infected by pneumocystis(1 Datient clinical diagnosis without aetiology proof).The levels of plasma(1→3)-β-D-slucan in invasive fungal infections patients were(105.02±82.22)ng/L,which were higherthan thosein healthy persons[(6.65±1.01)ng/L)J,P＜0.01.Conclusion The levels of plasma(1→3)-β-D-glucanisan ia an important index in diagnosis of invasive fungal infections.