Efficacy of transcatheter arterial chemoembolization combined with arsenic trioxide in the treatmet of primary liver cancer for 91 cases
- VernacularTitle:肝动脉栓塞联合三氧化二砷治疗原发性肝癌91例观察
- Author:
Shushi WANG
;
Ying CUI
;
Jun SUN
;
Tongzhong HAN
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Chemoemboliztion,therapeutic;
Arsenic trioxide
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(11):1805-1806
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the short term efficacy of transcatheter arterial chemoembolization(TA-CE)combined with arsenic trioxide(AS203) in the treatment of primary liver cancer.Methods 91 patients with advanced primary liver cancer underwent routine hepatic arterial chemoembolization,repeated every 4 weeks for 2 to 3 cycles.In each cycle of chemoembolization,AS2O3 ,was injected intravenously once a day for 2 weeks at a dose of 10～15mg.Results All patients completed 2～3 cycles treatment and followed for more than one year.Total response rate was 61.7% and clinical benefit rate was 42 cases of partial response(PR) ,35 cases of no changes(NC) and 11 cases of progressive disease(PD).Quality of life improved in 61 cases and stabilized in 24 cases.Toxicifies was mild and tolerable.Conclusion TACE combined with arsenic trioxide in the treatment of primary liver cancer is efficient with a mild toxicities.
