Effects of "glucotoxicity", "lipotoxicity" and "glucolipotoxicity" on islet β-cells
10.3760/cma.j.issn.1000-6699.2009.01.002
- VernacularTitle:胰岛β细胞的"糖毒性"、"脂毒性"与"糖脂毒性"
- Author:
Mingdao CHEN
- Publication Type:Journal Article
- Keywords:
Glucotoxicity;
Lipotoxicity;
Islet β-cells function
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(1):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Glucotoxicity, lipotoxicity and glucolipotoxieity are secondary phenomena following the primary pathogenesis, including the effects of genetic and environmental factors of type 2 diabetes. However, there exist two theories: (1) Lipotoxicity, presents before blood glucose rising, may trigger off a chain reaction which results in hyperglycemia. Hence the term " diabetes mellipidus" was proposed. (2) Hyperglycemia is a prerequisite for lipotoxicity. It seems more appropriate to state that (1) the glucotoxieity and iipotoxicity may present separately or concurrently in type 2 diabetes; (2) The combined glucolipotoxicity should describe the deleterious actions by higher levels of both glucose and free fatty acids on β-cell function, which finally causes progressive deterioration of insulin secretion.
