Study on pancreatic islet β-cell function and insulin sensitivity at different stages of lifetime in rats born with intrauterine growth retardation
10.3760/cma.j.issn.1000-6699.2009.01.026
- VernacularTitle:宫内发育迟缓大鼠不同阶段胰岛功能及胰岛素敏感性的研究
- Author:
Lu CHEN
;
Cuiping LIU
;
Kuanfeng XU
;
Xiaodong MAO
;
Qingxin YUAN
;
Chao LIU
- Publication Type:Journal Article
- Keywords:
Intrauterine growth retardation;
Diabetes mellitus,type 2;
Islet β-cell function;
Insulin sensitivity
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(1):87-89
- CountryChina
- Language:Chinese
-
Abstract:
The intrauterine growth retardation (IUGR) model was established by maternal nutrition restriction during mid- to late-gestation. IUGR rats had both impaired pancreatic development and islet β-cell dysfunction. As the animals grew, the rats gradually showed impaired glucose tolerance and decreased insulin sensitivity.
