The therapeutic effects of Chinese injectio xuebijing on promoting coagulant factors on dogs with septic shock
10.3760/cma.j.issn.1671-0282.2009.02.007
- VernacularTitle:中药注射液血必净对感染性休克犬促凝物质的影响
- Author:
Caijun WU
;
Chunsheng LI
- Publication Type:Journal Article
- Keywords:
Chinese injection;
Xuebijing;
Septic shock;
Coagulation;
Promote coagulation factors
- From:
Chinese Journal of Emergency Medicine
2009;18(2):140-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of injectio xuebijing (Chinese herb prepara-tions) on coagulat factors in dogs with septic shock. Method Eighteen dogs infected and shocked by intravenous endotoxin(LPS) were randomly divided into three groups: control group (n=6) treated with sodium chloride, dopamine group (n=6) treated with dopanfine, and dopamine plus xuebijing group (n=6) treated with dopamine and xuebijing. The therapeutic effects were assessed by comparison of the changes in VCAM (vascular cell adhe-sion molecule) ,ICAM (inter-cell adhesion molecule), VWF (yon willibrand factor) and PAI-I (plasminogen acti-vator inhibitor-1) at different indexes including the basic status, the dog being shocked without therapy, 3 and 7 hours after treatment.Analysis was made by SPSS 13.0 software. Results In xuebijing group, VCAM, ICAM, VWF and PAI-1 were signifieanfly changed 3 or 7 hours later after xuebijing administered rather than in control group and dopamine group (P<0.01 or P<0.05 ).In dopamine group, ICAM,VWF and PAI-1 were signiti-eanfly changed 3 or 7 hours after dopamine given rather than in control group (P<0.01 or P <0.05). Conclu-sions Injectio xuebijing obviously decreases the levels of coagulat factors in dogs with septic shock. Therfore, the injectio xuebijing can be used to treat the septic shock.
