Observation and nursing of irinotecan in combination with fluorouracil for advanced colorectal cancer
- VernacularTitle:伊立替康联合氟尿嘧啶治疗晚期大肠癌的护理
- Author:
Shuwei ZANG
;
Dongmei LIU
;
Hongjuan DING
;
Guangqun PENG
;
Yi MA
- Publication Type:Journal Article
- Keywords:
Intestinal neoplasms;
Irinotecan;
Fluorouracil;
Nursing care
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(11):1836-1837
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the major adverse reaction of irinotecan in combination with fluorouracil for advanced colorectal cancer,and sum up the nursing experience of acetylcholine syndrome and acute delayed diarrhea.Methods Pathologically confirmed 45 cases of patients with advanced colorectal cancer were treated with modified FOLFIRI regimen for total of 190 cycles.Results Acetylcholine syndrome rate was 28.9%,the incidence of acute delayed diarrhea was 40.0% ,more than 3 grade diarrhea was 6.7%.Conclusion The incidence of acute delayed diarrhea in Chinese patients is lower than in caucasians,and reasonable care measures can reduce the occurrence of adverse reactions,irinotecan in combination with fluorouracil is a safe and effective regimen for Chinese patients.
