The inhibiting effect of endostatin on transplant tumor of breast carcinoma MCF-7 cell in nude mice
10.3760/cma.j.issn.1673-4203.2009.01.005
- VernacularTitle:内皮抑素对乳腺癌MCF-7细胞裸鼠移植瘤的抑制作用
- Author:
Minyi ZHAO
;
Bo XU
;
Jintang XIA
;
Wensong CAI
;
Huanqing XIAO
- Publication Type:Journal Article
- Keywords:
endostatin;
breast carcinoma
- From:
International Journal of Surgery
2009;36(1):10-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe inhibiting effect of endostatin on subcutaneous transplant tumor of breast carcinoma, and to illuminate the therapeutic effect of endostatin in the cancer. Methods The effect of en-dostatin on MCF-7 cell proliferation was studied by MTr. The model of MCF-7 cell transplant tumor on nude mice was constructed. Endostatin was injected intradermally around the transplant tumor. Inhibition effect on the tumor was observed. Results Endostatin with the concentration of 10 μ/mL and 15 μg/mL can inhibitMCF-7 cell proliferation effectively (P < 0. 05 ). After endostatin injection, tumor weight, volume and mi-crovessel density decreased significantly(P < 0.05 ). Conclusion Endostatin can inhibit breast carcinoma proliferation through inhibiting angiogenesis and the tumor cell itself.
