Expression and significance of Smad4 in mice with hepatic alveolar echinococcosis ZHANG Ya-lou,MA
10.3760/cma.j.issn.1673-9752.2009.01.018
- VernacularTitle:Smad4在肝泡状棘球蚴病小鼠中的表达及其意义
- Author:
Yalou ZHANG
;
Hailong MA
;
Hui LIU
;
Xinwei QI
;
Tao LIU
;
Tao JIANG
;
Fengcai JI
;
Hao WEN
- Publication Type:Journal Article
- Keywords:
Echinocosis,hepatic;
Smad4 protein;
Transforming growth factor-βDOI:10.3760/cma.j.issn.1673-9752.2009.01.019
- From:
Chinese Journal of Digestive Surgery
2009;8(1):47-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of Smad4 in peripheral hepatocytes of lesions in mice with hepatic alveolar echinococcosis.Methods Eight mice in the test group were inoculated with alveolar echinococcosis and 8 mice in the control group were injected with normal saline.The expression of Smad4 protein in the hepatic tissue of the mice was detected by immunohistochemistry method,and the data were analyzed by chi-square test.The effect of alveolar echinocoeeosis on the expression of Smad4 protein was investigated.Results Smad4 was detected in cell nuclei and partly in the cytoplasm.Six months after the establishment of the mice model for alveolar echinococeosis,the expression of Smad4 in the hepatic tissue in the test group was significantly higher than in the control group(x2=19.869,P＜0.05).The number of Smad4 with positive expression in the hepatocytes in the test group was slightly higher than in the control group,and the expression intensity of Smad4 in the test group was greater than in the control group(x2=58.3 10,P＜0.05).Conclusions The increase of the expression of Smad4 protein in the periphery hepatocytes and tissues of hepatic alveolar echinococcosis lesions may play a role in hepatic cirrhosis and immune evasion.
