The value of detection of Pre S1 antigen of hepatitis B virus
10.3760/cma.j.issn.1008-6706.2009.01.029
- VernacularTitle:乙型肝炎病毒前Sl抗原检测的价值
- Author:
Zhongling TU
- Publication Type:Journal Article
- Keywords:
Pre S1 antigen;
Hepatitis B virus
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(1):55-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the value of detection of Pre S1 antigen(Pre-S1 Ag) of hepatitis B virus. Methods ELISA was used to detect Pre-S1 Ag and HBeAg in serum from 854 HBsAg-positive persons in medical ex-amination who have no symptom. In addition, Pre-S1Ag in serum from 300 random samples of HBsAg-negative persons were detected in medical examination. Results Pre-S1Ag positive rate was 41.1% (351/854) in 854 samples with HBsAg(+) ,and HBeAg positive rate was 26.6% (227/854) in them. Pre-S1 Ag positive rate was 79.7% (181/227) in HBeAg(+) group but was 27.1% (170/627) in HBeAg(-) group. Pre-S1 Ag wasn't detected in 300 samples with HBsAg(-). Conclusions In HBsAg-positive samples who have no symptom,the detection rate of Pre-SIAg is higher than that of HBeAg. Pre-Sl Ag can reflect duplication and infectivity of HBV better than HBeAg and it has more value to epidemiology investigation and clinical diagnosis than the latter.