Expression of FHIT gene in cervical carcinoma
10.3760/cma.j.issn.1008-6706.2009.01.035
- VernacularTitle:脆性组氨酸三联体基因在宫颈癌组织中的表达及临床意义
- Author:
Lili HAN
;
Yanbing LI
;
Huijun WANG
- Publication Type:Journal Article
- Keywords:
Cervical neoplasms;
Immunohistochemistry;
Fragila histidlne triad
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(1):65-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of fragile histidine triad (FHIT) gene in cervical carci-noma and relationship with its clinical-pathological implication. Methods The expression of FHIT was detected by immunohistochemistry SP method in 42 cases of cervical carcinoma and 13 cases of adjacent tissue. Results 47.6% (20 of 42) of cases expressed FttIT in the tumor cells,and 92.3% (12 of 13) of cases of the adjacent tissue were present. There was a significant positive correlation between cervical carcinoma and adjacent tissue(P <0.01). The positive rates of FHIT in high and middle desrees of differentiation were significantly higher than that in low degree of differentiation(54.2% vs 38.9%). Tumors with lymph node metastases(45.9%) had loss FHIT protein expression than those without metastasis(60.0%) (P <0.05). The FHIT expression between Ⅰ and Ⅱ stage,the difference was significant(55.0% vs 45.5%) (P < 0.05). Conclusion FHIT gene plays an improtant role in the occurrence and development of cervical carcinoma. It is suggested that FHIT can be a useful marker for predicting invasion and metas-tasis ability of cervical carcinoma.
