Combination of glucotoxicity and lipitoxicity impairs pancreatic β-cell function
10.3760/cma.j.issn.1000-6699.2009.01.008
- VernacularTitle:糖脂联合毒性导致胰岛β细胞功能障碍
- Author:
Naiqian ZHAO
;
Yerong YU
;
Huiwen TAN
;
Xiangxun ZHANG
- Publication Type:Journal Article
- Keywords:
Glucotoxicity;
Lipitoxicity;
Islet β-cell function;
Ketone production
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(1):28-29
- CountryChina
- Language:Chinese
-
Abstract:
The effects of elevated levels of glucose and (or) free fatty acids on insulin secretion were studied in obese rats by intravenous glucose tolerance test and isolated pancreas perfusinn. The results showed that both glucose- and arginine-stimulated insulin secretions were severely impaired by glucolipotoxicity and the production of ketone was increased dramatically.
