Study on hNIS mediated transferring gene99mTcO-4 imaging and mI treatment in xenografted ovariancancer

VernacularTitle:转染甲状腺钠/碘同向转运体的卵巢癌99m TcO-4显像及131Ⅰ治疗
Author: Jingqiu CUI ; Peihua FANG ; Ning LI ; Ping FENG ; Jian TAN
Publication Type:Journal Article
Keywords: Human sodium/iodide symporter; 99mTcO-4 imaging; 131Ⅰ treatment; Ovarian cancer
From: Chinese Journal of Endocrinology and Metabolism 2009;25(1):83-86
CountryChina
Language:Chinese
Abstract: Objective To establish radioiodine therapy in nonthyroid tumor and to investigate 131Ⅰ treatment effect on xenografted ovarian cancer. Methods Based on previous test, xenografted ovarian cancer nude model were established in nude mice. The effects of radioactive isotope 99m TcO-4 imaging and radioiodine 131Ⅰ treatment on xenografted ovarian cancer in vivo were investigated. Results After transferring human sodium/iodide symporter (hNIS) gene, the xenografted ovarian cancer in nude mice was imaged by isotope 99m TcO-4 Moreover,131Ⅰ exerted inhibitory effect on the proliferative activity. Conclusion After the transfection of hNIS gene, 131Ⅰ has inhibitory effect on proliferative activity of xenografted ovarian cancer.