Effect of glucocorticoid on the expression of PGC-1α mRNA in brown adipose tissue and skeletal muscle of obese rats fed with high-fat diet
10.3760/cma.j.issn.1000-6699.2009.01.028
- VernacularTitle:糖皮质激素对高脂饮食肥胖大鼠棕色脂肪和骨骼肌PGC-1αmRNA表达的影响
- Author:
Xiaolei HU
;
Jianhua SHI
;
Ping XIANG
;
Yanping FAN
;
Yanjun MIAO
;
Yongqi HUANG
- Publication Type:Journal Article
- Keywords:
Obesity;
PGC-1α;
Glucocorticoids;
Rats
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(1):92-94
- CountryChina
- Language:Chinese
-
Abstract:
Real-time fluorescent quantitative PCR was used to examine PGC-1α mRNA expression in brown adipose tissue and skeletal muscle of rats. The results showed that the expression levels of PGC-1α mRNA in brown adipose tissue and skeletal muscle of obese rats were lower than those of the normal ones (all P<0.01). After high dose glucocorticoid treatment, the levels of PGC-1α mRNA expression in brown adipose tissue and skeletal muscle, both in normal and obese rats, were decreased significantly.
