The relationship between MMP——3 expression and gastric cancer invasion and metastasis
- VernacularTitle:基质金属蛋白酶——3表达与胃癌侵袭和转移的关系
- Author:
Churong WU
- Publication Type:Journal Article
- Keywords:
MMP-3;
Stomach neoplasms;
Immunohistochemistry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(11):1790-1791
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of matrix metalloproteinase (MMP-3)and degree of invasion and lymph node metastasis.Methods 60 paraffin-embedded samples of gastric cancer and para-cancer from surgically resected tissues were selected,15 biopsied endoscopically samples of chronic surface gastritis were served as controls.The expression of MMP-3 proteins were examined by immunohistochemical method.Results Positive expression rates of MMP-3 in samples from cancerous tissue was 60.0%,those of MMP-3in matched para-cancer tissues was 16.7% ,the positive expression rates of cancerous tissue was significantly higher than those of para-cancer tissue(P <0.05).The expression of MMP-3 correlated statistically with the lymph node metastasis and cancer stage.There was high significant relationship among the MMP-3 protein expression(P <0.05 ).The lymph node metastasis rate of tissues with positive expression of two or more parameters was significantly higher than tissues with positive expression of only one or none parameter(P <0.05).Conclusion There was significant correlation between MMP-3 expression degree and gastric cancer staging and lymph node metastasis.MMP-3 expression degree is a valuable index for the judgment of gastric cancer stage and metastasis.
