SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer.
10.4142/jvs.2012.13.2.211
- Author:
Jung Taek KANG
1
;
Hyung Jin KIM
;
Hyun Ju OH
;
So Gun HONG
;
Jung Eun PARK
;
Min Jung KIM
;
Min Kyu KIM
;
Goo JANG
;
Dae Yong KIM
;
Byeong Chun LEE
Author Information
1. Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. bclee@snu.ac.kr
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
hermaphrodite;
intersexuality;
wolf
- MeSH:
Animals;
Cloning, Organism/*veterinary;
Female;
Karyotyping;
Mutation;
Nuclear Transfer Techniques/*veterinary;
Ovotesticular Disorders of Sex Development/pathology/*veterinary;
*Wolves
- From:Journal of Veterinary Science
2012;13(2):211-213
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes.
