The association of primary liver cancer with the mutations in basic core promoter and precore genes of hepatitis B virus
10.3760/cma.j.issn.1674-2397.2009.01.006
- VernacularTitle:原发性肝癌与乙型肝炎病毒基本核心启动子和前C区基因变异的相关性
- Author:
Yongxi TONG
;
Lanjuan LI
;
Guoqiang LOU
;
Yongle ZHANG
;
Nianbo ZHAO
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Primary liver cancer;
Basic core promoter;
Preeore gene;
Mutation
- From:
Chinese Journal of Clinical Infectious Diseases
2009;2(1):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of primary liver cancer(PLC)with the mutations of HBV precore and basic core promoter(BCP)genes.Methods The serum markers of hepatitis B and the quantities of serum HBV DNA were detected in 144 HBsAg-positive PLC patients.The precore and BCP gene mutations in patients with HBeAg-negtive and HBV DNA-positive were detected by real-time PCR.One hundred and twenty chronic hepatitis B(CHB)patients were randomly selected to serve as the conol.Results There were 46(3 1.94%)patients with HBeAg-positive and 98(68.06%)patients with HBeAg-negative.In 98 HBeAg-negative patients,56(57.14%)were HBV DNA-positive,in which 43 (76.79%)were with precore 1896 gene mutations,50(89.29%)were with BCP1762/1764 gene mutations.and 38(67.86%)were with both gene mutations.Precore 1896 and BCP1762/1764 gene mutation rates in PLC patients were much higher than those in CHB patients(χ2=9.36 and 5.77,P＜0.05).Conclusion PLC may be associated with the mutations of HBV precore anti BCP genes.
