Comparison of the excursion of blood glucose in type 2 diabetes injected glargine and human isophane insulin

VernacularTitle:加用甘精胰岛素或中效胰岛素的2型糖尿病患者血糖波动的比较
Author: Longyi ZENG ; Panwei MU ; Guochao ZHANG ; Yanming CHEN ; Jingyi FU ; Manman WANG
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Glargine; Human isophane insulin; Blood glucose excursion
From: Chinese Journal of Endocrinology and Metabolism 2009;25(1):39-41
CountryChina
Language:Chinese
Abstract: Objective To compare the excursion of blood glucose (BG) in the type 2 diabetes mellitus treated with oral antidiabetic drugs (OADs) plus glargine or human isophane insulin (HII). Methods A 1 : 1 randomization schedule assigned 30 type 2 diabetics inadequately controlled on OADs (fasting BG>9.0 mmol/L and HbA1C > 8.5%) to 2 groups additionally treated with glargine or HII. The insulin dose was titrated to achieve fasting capillary BG<6.0 mmol/L. Montoring BG with continuous glucose monitoring system, then the standard deviation of BG (SDBG), maximal excursion of BG (LAGE) and coefficient of variation (CV) of fasting plasma glucose (FPG) were calculated. Results SDBG (1.49±0.35 vs 1.73±0.46), LAGE (3.23±0.76 vs 3.73± 1.00) and CV-FPG (17.26±2.24 vs 20.33±3.21) were lower in glargine group than those in HII group (P< 0.05). No difference could be found in hypoglycaemia between two groups. Conclusion OADs plus glargine could make blood glucose more stable than OADs plus HII without increasing the incidence of hypoglycaemia.