Notch signaling pathway and clinicopathology in human gastric cancer

VernacularTitle:Notch信号通路在胃癌组织中的表达及其意义
Author: Xiaodong YANG ; Hui ZHANG ; Zigang BAI ; Kewei JIANG ; Yingjiang YE ; Shan WANG
Publication Type:Journal Article
Keywords: Stomach neoplasms; NF-kappa B; Signal pathway
From: Chinese Journal of General Surgery 2009;24(2):146-148
CountryChina
Language:Chinese
Abstract: Objective To investigate Notch signaling pathway expression and its relationship with clinicopathological parameters in human gastric cancer.Methods Specimens of carcinoma tissues and nodal gastric membrane were obtained from 63 gastric cancer patients undergoing radical surgery from Jan 1999 to Dec 2001.Notehl,Deltal,Jaggedl and NFKB protein were measured using fissure microarray and immunohistochemistry.Data were analysed using SPSS software.Results Notchl,Deltal,Jaggedl and NFKB protein were upregulated in gastric cancer tissue compared with adjacent normal tissue(P＜0.01).The expression of Notchl protein in the well--differentiated tumors was higher than that in the poordifferentiated tumors(P＜0.05).Positive linear correlation was established between the expression of Jaggedl and NFkB.Conclusion Notchl signal transduction pathway plays an important role in the development of human gastric cancer by activation of NFKB through Notchl-Jaggedl signal transduction pathway.It is also evident that Notch signaling can be both oncogenic and tumor suppressive in human gastric cancer.