Expression and clinical significance of p27 protein in stage Ⅱ colon cancer
10.3760/cma.j.issn.1673-9752.2009.01.021
- VernacularTitle:p27蛋白在Ⅱ期结肠癌组织中的表达及其意义
- Author:
Bangling CHEN
;
Ming LI
;
Bin DONG
;
Jin GU
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Stage Ⅱ;
p27 protein;
Prognosis
- From:
Chinese Journal of Digestive Surgery
2009;8(1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of p27 protein in stage Ⅱ colon cancer.Methods The expression of p27 protein in 57 samples of stage Ⅱ colon cancer tissue from BeijingCancer Hospital was detected by immunohistochemistry and tissue microarray technique.Survival was analyzed by the Kaplan-Meier method,and the correlation between the expression of p27 protein and the prognosis of patients was analyzed by Pearson chi-square test.Multivariate analysis was done by using Cox proportional hazard regression model.Results The rate of high expression of p27 protein in stage Ⅱ colon cancer was 60%(34/57).The differentiation.location and distal metastasis of the tumor were correlated with the expression of p27 protein(X2=5.97,5.93,5.05,P＜0.05);while age,tumor size,growth patterns of tumor were not correlated with the expression of p27 protein(X2=0.64,0.49,0.33,P＞0.05).The 5-year survival rate of the patients with high expression of p27 protein was 94%(32/34),which was significantly higher than the 78%(18/23)of the patients with low expression of p27 protein(X2=3.86,P＜0.05).Multivariate analysis showed that low expression of p27 protein and tumor penetrating serous membrane are the independent adverse prognostic factors for stage Ⅱ coloR cancer.Conclusions Low expression of p27 protein is one of the independent adverse prognostic factors for stage Ⅱ colon cancer,and the expression of p27 protein should be consulted when screening out the patients who are in the high risk group of stage Ⅱ colon cancer.
