Clinical Analysis of primary Sjogren Syndrome with Hematological damages

VernacularTitle:原发性干燥综合征伴血液系统损害的临床分析
Author: Yufeng QING ; Jingguo ZHOU ; Minghui YANG ; Guohua YUAN
Publication Type:Journal Article
Keywords: Sj(o)gren's syndrome; Hematoeytopenia; Medullary substance of bones
From: Chinese Journal of Rheumatology 2009;13(2):117-119
CountryChina
Language:Chinese
Abstract: Objective To explore the characteristics of hematological changes in patients with primary Sj(o)gren'syndrome (pSS).Methods The clinical data of 49 cases with pSS were retrospectively analyzed.Resuits The data showed that 25 patients (51%) among 49 cases had hematological changes.of which 15 cases were anaemia (31%).8(16%) were leukopenia,and 10 cases (20%) were thrombocytopenia.And 6 cases had two cell lines involved.2 cases had three cell lines involved.Twenty-three bone marrow aspirations revealed active proliferation or normal cell proliferation and the morphology of all 3 cells lines were normal.Bone marrow examination had strong positive iton stain and 15 cases with anaemia showed positive iron stain.Seven out of 10 patients with thrombocytopenia had megakaryocyte maturation defect.Conclusion Hemotologieal changes are common.and anemia is the most common findings.Cytopenia is related to autoantibodies mediated stem cell damages.but anemia iS caused by iron metabolic disturbance.while thrombocytopenia is generally due to functional impairment of megakaryocytes.