Splenic radiofrequence ablation and cell immunity in hypersplenism
10.3760/cma.j.issn.1007-631X.2009.02.010
- VernacularTitle:射频消融治疗脾功能亢进症对机体细胞免疫功能的影响
- Author:
Kai FENG
;
Kuansheng MA
;
Jun GAO
;
Nianzhou LIU
;
Jiahong DONG
;
Shuguang WANG
- Publication Type:Journal Article
- Keywords:
Hypersplenism;
Catheter ablation;
Immunity,cellular;
Splenectomy
- From:
Chinese Journal of General Surgery
2009;24(2):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the short and long term result and the impact on cell immunity of splenic radiofrequence ablation in patients with hypersplenism.Methods In this study 43 patients were divided into the RFA treatment group(22 cases)and open splenectomy control group(21 cases).Blood samples were collected for blood routine,lymphocyte transformation efficiency,NK cell activity and T lymphocyte subpopulations at 1 week,1 month,6 month,1 year,2 years and 3 years before and after operation respectively and the results were compared between the two groups.Results The hypersplenism of the patients in both groups were relieved.There were no significant difierences in cell indices between the postoperative and preoperative values in the two groups.In the control group,compared with the preoperative values in the trial group,the postoperative NK cell activity and lymphocyte transformation efficiency were significantly reduced(P＜0.05).Even though,with time,the NK cell activity and lymphocyte transformation efficiency were on an increasing tendency after operation but still significantly lower than that before operation.In the control group,compared with the preoperative values,CD4+T cell count and CD4+/CD8+ratio decreased significantly(P＜0.05).Moreover.with time.these indices were on an increasing tendency.CIM+T cell count and CD4+/CD8+ ratio restored to the preoperative values within 30 months(P=0.078)and 36 months(P=0.103)respectively.Conclusion RFA treatment for hypersplenism preserves a part of the spleen and thus preserves patient's cell immunity.This treatment exhibits microinvasiveness and few complications and being easy to operate.Hence,RFA treatment for hypersplenism merits wide clinical application.
