Clinical investigation of mycophenolate mofetil treatment for refractory autoimmune liver disease
10.3760/cma.j.issn.1007-7480.2009.02.012
- VernacularTitle:吗替麦考酚酯治疗难治性自身免疫性肝病的临床研究
- Author:
Gailian ZHANG
;
Feng HUANG
;
Huiqin HAO
- Publication Type:Journal Article
- Keywords:
Autoimmune liver disease;
Autoimmune hepatitis;
Primary biliary cirrhosis;
Mycophe-nolate mofetil:Treatment effect
- From:
Chinese Journal of Rheumatology
2009;13(2):114-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of mycophenolate mofetil (MMF) for refractory autoimmune 1iver disease:Methods Six patients with autoimmune liver disease who had failed MMF treatment and variation of biochemical indexes.adverse effects of the MMF treatment were recorded.Results After MMF treatment.the serum 1evels of alanine aminotransferase (ALT) were decreased to nOrmal level in three of four patients with higher ALT.The serum levels of alkaline phosphatase (ALP) were decreased to more than fifty percent of normal level in four of five patients with higher ALP.The serum levels of γ-glutamyhransferase (GGT) were decreased to more than fifty percent of normal level in all five patients with higher GGT.The serum levels of immunoglobulin G (IgG) and γ-globulin were decreased to normal level in all two patients who had elevated IgG and r-globulin levels.The serum levels of total bilirublin and total bile acid.the count of white blood cell and platelet had no change.There were no adverse effects in a11 six patients.Conclusion MMF treatment for early refactory autoimmune liver disease is effective with few sideeffects.
