A correlative study on the changes of blood gas, plasma fibrinogen and D-dimmer in neonates with hya-line membrane disease

VernacularTitle:肺透明膜病患儿血气及凝血功能的变化及相关性分析
Author: Tong YANG ; Xianwen HUANG ; Xiping LIN
Publication Type:Journal Article
Keywords: Hyaline membrane disease; Blood gas analysis; Fibrinogen; D-dimmer
From: Chinese Pediatric Emergency Medicine 2009;16(1):37-38
CountryChina
Language:Chinese
Abstract: Objective To explore the changes of blood gas, plasma fibrinogen and D-dimmer levels in neonates with severe hyaline membrane disease (HMD). Methods Forty - three neonates with severe HMD(treated by mechanical ventilation) ,26 neonates with mild HMD( without treated by mechanical venti-lation) and 31 controls were studied. The blood gas,plasma fibrinogen and D-dimmer levels were measured. Results Compared with other two groups, the levels of blood pH, PaO2 and FBG decreased significantly in neonates with severe HMD (P<0.01). The levels of PaCO2 and D-dimmer increased significantly (P<0.01). The blood pH was negatively correlated with plasma D-dimmer level,but it was positively correlated with plasma FBG level in neonates with severe HMD. Conclusion There are coagulation abnormalities in neonates with severe HMD. Hypoxemia and acidosis have close relationship with the coagulation abnormali-ties.