Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity.
- Author:
Hye Jeong LEE
1
;
Yoon Kyung SHIN
;
Hwan Tae PARK
Author Information
- Publication Type:Review
- Keywords: Schwann cell; dedifferentiation; plasticity; nerve injury; mitogen activated protein kinase family proteins; c-jun
- MeSH: Action Potentials; Axons; Humans; Myelin Sheath; Nerve Growth Factors; Neuregulin-1; Peripheral Nerve Injuries; Peripheral Nerves; Phosphotransferases; Plastics*; Protein Kinases*; Regeneration; Schwann Cells; Transcription Factors
- From:Experimental Neurobiology 2014;23(2):130-137
- CountryRepublic of Korea
- Language:English
- Abstract: Schwann cells (SCs) in the peripheral nerves myelinate axons during postnatal development to allow saltatory conduction of nerve impulses. Well-organized structures of myelin sheathes are maintained throughout life unless nerves are insulted. After peripheral nerve injury, unidentified signals from injured nerves drive SC dedifferentiation into an immature state. Dedifferentiated SCs participate in axonal regeneration by producing neurotrophic factors and removing degenerating nerve debris. In this review, we focus on the role of mitogen activated protein kinase family proteins (MAP kinases) in SC dedifferentiation. In addition, we will highlight neuregulin 1 and the transcription factor c-jun as upstream and downstream signals for MAP kinases in SC responses to nerve injury.
