Effect of telmisartan on insulin resistance in elderly patients undergoing maintenance hemodialysis
10.3760/cma.j.issn.1671-7368.2009.02.021
- VernacularTitle:替米沙坦对老年维持性血液透析患者胰岛素抵抗的影响
- Author:
Rui WANG
;
Guohua DING
;
Hongyan LIU
- Publication Type:Journal Article
- Keywords:
Hemodialysis;
Telmisartan
- From:
Chinese Journal of General Practitioners
2009;8(2):129-131
- CountryChina
- Language:Chinese
-
Abstract:
Eleven elderly patients undergoing maintenance hemodialysis without ARB or ACEI within 4 weeks were enrolled. Anti-hypertensive agents were replaced by telmisartan gradually to maintain stable blood pressure. Before and after 6 or 12 weeks of treatment, blood biochemical profiles, fasting blood glucose, fasting plasma insulin, insulin resistance index(HOMA-IR), blood pressure, and body weight were recorded. Our results showed that telmisartan did not affect body weight, high-density lipoprotein (HDL), triglyceride (TG), SCr, BUN, Alb, K+ , and PTH, although led to a significant decrease in TC and low-density lipoprotein (LDL). Following telmisartan treatment, FPG did not change significantly, but fasting insulin decreased from 13.9±3.6 mU/ml to 9.9±2.7 or 9.1±2.3 mU/ml at 6 and 12 week (P<0.01), and HOMA-IR decreased from 3.5±1.4 to 2.4±0.8 or 2.2±0.8 at 6 and 12 week (P<0.05). These results suggest that insulin resistance in elderly patients with MHD may be improved by telmisartan.