Protective effects of pentoxifylline on gastric mucosal injury in rats with endotoxemia
10.3760/cma.j.issn.1008-6706.2009.01.006
- VernacularTitle:己酮可可碱对内毒素血症大鼠胃黏膜损伤的保护作用
- Author:
Junda LIU
;
Xiuyin YE
;
Yumin HE
;
Xiaohe ZHENG
- Publication Type:Journal Article
- Keywords:
Pentoxifylline;
Endotoxemia;
Gastric mucosa;
injury;
Intercellular adhesion molecule-1
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(1):12-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of pentoxifylline on gastric mucosal injury in rats with endotoxemia. Methods 30 Wistar rats were randomly divided into 3 groups : sham operated control group (C group) ,LPS group and PTX group. The serum tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) levels in each group were measured. The immunohistochemistry was used to assess the expression of the ICAM-1 in the gastric mucosal tissues. Results The levels of TNF-α and IL-1β in serum in LPS group were higher than those in C group (P <0.01). The level of ICAM-1 in the gastric mucosal tissues in LPS group was higher than those in sham operated control group(P < 0.01). After FIX treatment, the levels of TNF-α and IL-1β in serum in PTX group were lower than those in LPS group(P < 0.01) and the level of ICAM-1 in the hepatic tissues in PTX group was also lower than those in LPS group(P <0.01). Conclusions TNF-α,IL-1β and ICAM-1 take part in the progress of gastric mucosal inju-ry in rats with endotoxemia. PTX can eliminate the gastric mueesa injury and protect the gastric mucosal tissues by downregulating the levels of TNF-α, IL-1β and ICAM-1.
