Clinical observation on precaution effect of ephedrine on protamine's untoward reaction

VernacularTitle:麻黄碱预防鱼精蛋白不良反应的临床观察
Author: Hua WEI ; Jinsong DENG
Publication Type:Journal Article
Keywords: Ephedrine; Protaminer; Untoward reaction
From:Chinese Journal of Primary Medicine and Pharmacy 2009;16(1):48-49
CountryChina
Language:Chinese
Abstract: Objective To investigate precaution effect of ephedrine on protamine's untoward reaction. Meth-ods Forty patients, who were scheduled to have mitml valve replacement operation were randomly divided into two groups: ephedrine group(group A, n = 20) and control group (group B, n = 20). 50ml solution, mixed with protamine and 5% glucose,was injected through internal jugular vein in five minutes to neutralize the effect of heparin. In group A,3mg ephedrine was added into neutralization solution while in group B nothing was added. Arterial pressure(AP) , heart rate(HB) peripheral hemoglobin oxygen saturation(SpO2) and airway resistance(AR) were measured before injection and 1,3,5,10 minutes after injection in both groups. Results In group A, the AP, HR, SpO2 and AR had no significant difference before and after injection (P >0.05) ;while in 6 eases of group B, the AP, HR, SpO2 and AR have significant difference before and after injection. Conclusion Ephedrine can significantly improve protamine's untoward reaction, and neutralize the effect of heparin.