Apoptosis inhibition and chemosensitivities in GI carcinomas
10.3760/cma.j.issn.1007-631X.2009.02.020
- VernacularTitle:消化道肿瘤凋亡抑制蛋白表达与体外化疗药物敏感性的关系
- Author:
Jie HAN
;
Jianhui ZHAO
;
Bibo TAN
;
Wei GENG
;
Bingrong LU
;
Chunnian HE
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Colorectal neoplasms;
Tumor suppressor,protein p53;
Proto-oncogene proteins c-bcl-2: Apoptosis:Drug resistance,neoplasm
- From:
Chinese Journal of General Surgery
2009;24(2):149-152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of inhibition of apoptosis proteins like p53,survivin,bcl-2 and chemosensitivities in gastrointestinal tract carcinomas.Methods The expression of p53,survivin and bcl-2 were determined immunohjstochemically,and the chemosenisitivities to 9 drugs was measured by MTT assay in 84 tissue specimens of gastrointestinal carcinomas.Resuits Positive immunostainning for p53,survivin and bcl-2 were found in 64%,89%and 61%of cases.respectively.Correlation existed between the expression of Sllrvivin and bcl-2(r=0.3027,P＜0.05).In terms of relationship between expression of p53,survivin or bcl-2 and inhibition rates of tumor cells.the inhibition rates to PTX and DDP in p53 strong expression group were lower than those in weak group(t=2.1282,P:0.0363;t=3.8850,P=0.0002).When survivin expressed strongly,the inhibition rates for VCR and DDP decreased significantly(t=2.1693,P=0.0329;t=2.0247,P=0.0046),while that for OXA increased(t=-2.9070,P:0.0047).here were lower tumor inhibition rates for 5-FU.VCR,eADM and OXA in bcl-2 strong expression group than those in weak group(t=2.1483～3.2330,P=0.0347～0.0018,respectively).Conclusions The extent of the expression of P53.survivin or bcl-2 in gastrointestinal carcinomas was associated with the chemosensitivities of some drugs.In assessing the influence of p53,survivin or bcl-2 on durg resistance,many factors and mechanisms should be considered.
