Clinicopathology, prognosis and EG-1 mRNA in breast cancer

VernacularTitle:乳腺癌组织中EG-1 mRNA的表达与临床病理特征及预后的关系
Author: Minghua CONG ; Qi LIU ; Zhaohua YANG ; Jian ZHU ; Xingsong TIAN
Publication Type:Journal Article
Keywords: Breast neopalsms; Oncogenes; Tumor markers,biological; Prognosis; EG-1
From: Chinese Journal of General Surgery 2009;24(2):156-159
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between the expression of EG-1 in breast cancer and the clinicopathological factors and prognosis of breast cancer.Methods EG-1 mRNA expression in 72 malignant and 18 benign breast tissues were evaluated by RT-PCR method,and its correlation with clinical characteristics and prognosis were retrospectively analyzed.Results EG-1 expression level was higher in malignant tissue than in the corresponding benign breast tissue(71%vs.24%,P＜0.05).EG-1 expression was significantly correlated with lymph node metastasis and protein VEGF (P＜0.05)and was not significantly with age,menopause,tnmor size,grade,hormone status,protein Her2 and pS3.The metastastic rate and recurrence rate in EG-1 positive patients was higher than that in EG-1 negative patients.Multivariate Cox model showed that EG-1 positive was an independent factor affecting overall survival and disease free survival.Conclusions EG-1 expression was up-regulated in breast cancer and significantly correlated with lymph node metastasis and protein VEGF.