Paradoxical role of Kupffer cells on ischemia/reperfusion injury in liver transplantation
10.3760/cma.j.issn.1673-4203.2009.02.009
- VernacularTitle:Kupffer细胞在肝移植缺血再灌注损伤中的双重作用
- Author:
Hanfei HUANG
;
Zhong ZENG
- Publication Type:Journal Article
- Keywords:
Kupffer cells;
ischemia/reperfusion injury;
liver transplantation
- From:
International Journal of Surgery
2009;36(2):94-97
- CountryChina
- Language:Chinese
-
Abstract:
Kupffer cells, the resident macrophages of the liver, play an important role in ischemia/reperfusion(L/R)injury in liver transplantation. 1schemic liver is reperfused through portal vein, and then Kupffer cells are activated. The liver is damaged by the released reactive oxygen species, inflammatory mediators and cytokines. On the other hand, upregulation of HO-1, induced by the activated kupffer cells, exerts a cytoprotective function for the IYR injury in liver transplantation models. Thus, Kupffer cells play the dual role on L/R injury in liver transplantation.
