Study on correlation between platelet activation and systemic inflammatory response syndrome in patients with acute ischemic stroke
10.3760/cma.j.issn.0254-9026.2009.02.032
- VernacularTitle:急性缺血性脑卒中患者血小板活化水平与全身炎症反应综合征的相关性
- Author:
Shixin XU
;
Jie GENG
;
Zhenxia XIAO
- Publication Type:Journal Article
- Keywords:
Cerebrovascular accident;
Systemic inflammatory response syndrome;
Platelet activation
- From:
Chinese Journal of Geriatrics
2009;28(2):100-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the dynamic level of platelet activation and to analyze the correlation between platelet activation and systemic inflammatory response syndrome(SIRS)in patients with acute ischemie stroke. Methods Mean platelet component concentration(MPC)and white blood count(WBC)were serially determined in patients with acute isehemic stroke,and other parameters including initial plasma fibrinogen(FIB)and adenosine diphosphate(ADP)aggregative rate were also determined.All parameters were compared between the SIRS group and the non-SIRS group.Correlation was analyzed between initial MPC and SIRS score,WBC,FIB and ADP aggregative rate. Results MPC level was declined slightly on the first day,and was followed by a relatively low MPC level from the second day to the forty-fifth day.The average level was fluctuated between 229 g/L and 242 g/L.There was no significant difference in initial FIB(t=1.835,P=0.07)between the SIRS group and the non-SIRS group,but the differences of other parameters had statistical significance(all P＜0.01).In the first three days,MPC level was negatively correlated with SIRS score(r=-0.392,-0.376,-0.341,t=3.484,3.405,3.125 respectively,all P＜0.01),but not correlated with WBC,FIB and ADP aggregative rate(P＞0.05). Conclusions Platelets maintain an activated state during the entire course of ischemic stroke.The initial level of platelet activation.WBC count and ADP aggregative rate are higher in SIRS patients than in non-SIRS patients.The initial level of platelet activation suggests the severity of SIRS,and may be one of the independent risk factors for SIRS.
