Polymorphism of angiotension Ⅱ type 1 receptor gene, angiotensin converting enzyme gene and aldosterone synthase gene and hypertensive disorder complicating pregnancy
10.3760/cma.j.issn.1008-6315.2009.02.004
- VernacularTitle:AT1R基因、ACE基因和CYP基因多态性与妊娠期高血压疾病的相关性研究
- Author:
Jianqing NIU
;
Hongfen LI
;
Zhixia SHEN
;
Shuying FAN
;
Qi DAI
;
Yunxia ZHANG
- Publication Type:Journal Article
- Keywords:
Hypertensive disorder complicating pregnancy;
Angiotensin Ⅱ type 1 receptor gene;
An-giotensin converting enzyme;
Aldosterone synthase gene;
Gene polymorphism
- From:
Clinical Medicine of China
2009;25(2):121-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship among genetic polymorphism of angiotension Ⅱ type 1 re-ceptor(AT1 R) A1166-C, angiotensin converting enzyme (ACE) insertion/deletion (I/D), aldosterone synthase (CYP11B2)-344T/C and hypertensive disorder complicating pregnancy.Methods Polymerase chain reaction-re-striction fragment length polymorphism (PCR-RFLP) assay was used to detect the genotypes of AT1 R A1166-C ,ACE (I/O) ,CYP11B2 -344T/C in 86 cases of hypertensive disorder complicating pregnancy and 175 cases of normal control.Results There was 18 combined types in hypertensive disorder complicating pregnancy cases and normal control cases.Compared to AT1R-AA + ACE-Ⅱ + CYP11B2-TT, Odds ratios (OR) of AT1R-AA + ACE-DO +CYP11B2-TC,AT1 R-AC + ACE-ID+CYP11B2-TC and AT1R-AC+ACE-DD+CYP11B2-TC are 7.289,5.315 and 5.694 respectively.There was no statistical significance among the others.Conclusion In all 18 kinds of combined types, AT1 R-AA + ACE-DO + CYP11B2-TC,AT1R-AC+ACE-ID+CYP11B2-TC and AT1 R-AC + ACE-DD +CYP11B2-TC might increase the susceptibility of hypertensive disorder complicating pregnancy.It is possible that multigenes are interacted in the etiology of hypertensive disorder complicating pregnancy.
