Distribution of six genes of essential hypertension In Yunnan Han healthy population
10.3760/cma.j.issn.1008-6315.2009.02.009
- VernacularTitle:云南省汉族健康人群六个原发性高血压候选基因多态性分布
- Author:
Xiaoli ZHAO
;
Dachun HU
;
Jianchun SHAO
;
Jing QIAN
;
Hongqing ZHANG
;
Jie JIANG
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Angiotensinogen;
Angiotensin converting enzyme;
Endothelio-ni-tricoxide synthase;
Endothelin-2;
Atrial natriureti;
peptide;
Natriuretic-peptide receptor;
Polymorphism
- From:
Clinical Medicine of China
2009;25(2):135-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distribution of RAS,AGT,ACE,eNOS,ET-2,ANP and NPRC of es-sential hypertension in Yunnan Han healthy population.Methods Gene chip technology was used to detect the pol-ymorphism of AGT M235T (MM, MT,TT), ACE I/D (II, ID, DD ), eNOS Glu298Asp (EE, ED, DD), ET-2 A985G (AA,AG,GG) ,ANP T2238C(TT,TC,CC) and NPRC A-55C(AA,AC,CC) in 97 health subjects.Results The MM,MT and TT genotype frequency of AGT M235T was 0.052,0.381 and 0.567 ,alle frequency of M and T was 0.242 and 0.758 in 97 healthy subjects of Yunnan population;The II, ID and DD frequency of ACE I/D was 0.340, 0.598 and 0.062, alle frequency of I and D was 0.680 and 0.320 in 97 healthy subjects of Yunnan population ;EE, ED and DD frequency of eNOS Glu 298 Asp was 0.845,0.144 and 0.011 ,alle frequency of E and D was 0.918 and 0.082 in 97 healthy subjects of Yannan population;AA,AG,GG frequency of ET-2 A985G was 0.020,0.258 and 0.722, alle frequency of A and G was 0.149 and 0.851 in 97 healthy subjects of Yunnan population;TT and TC fre-quency of ANP T2238C was 0.959 and 0.041 ,and CC was not detected;alle frequency of T and C was 0.979 and 0.021 in 97 healthy subjects of Yunnan population;AC and CC frequency of NPRC A-55C was 0.763 and 0.237, and no AA was detected,alle frequency of A and C was 0.381 and 0.619 in 97 healthy subjects of Yunnan popula-tion.Conclusion The polymorpbism of ACT M235T,ACE I/D,eNOS Glu298Asp,ET-2 A985G,ANP T2238C and NPRC A-55C is locally distributed in Yunnan Han healthy population.
