Expression and clinical significance of matrix metalloproteinase and matrix metulloproteinase tissue inhibiting factor-1 in colorectal carcinomas
10.3760/cma.j.issn.1008-6315.2009.02.012
- VernacularTitle:大肠癌组织中基质金属蛋白酶-9及其抑制物的表达和临床意义
- Author:
Dezhi GUO
;
Baoliang ZHANG
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma;
Matrix metalloproteinase-9;
Matrix metalloproteinase tissue inhibi-ting factor-1;
Immunohistochemistry
- From:Clinical Medicine of China
2009;25(2):143-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinicopathological significance of matrix metallo-proteinase(MMP-9) and matrix metalloproteinase tissue inhibiting factor-1 (TIMP-1) in colorectal carcinomas.Methods Immunohistochemistry (PowerVision method) in the paraffin embedded tissue samples was used to deter-mine MMP-9 and TIMP-1 in 42 colorectal carcinomas and its adjacent normal colorectal mucosa.The relationship of their expression with some clinicopathological characteristics was analyzed.Results MMP-9 and TIMP-1 were both significantly overexpressed in colorectal carcinomas compared with its adjacent normal colorectal mucosa(69.1% and 61.9% vs.45.2% and 40.5% ,P =0.009 and P =0.004) ,and MMP-9 was positively associated with the re-gional lymph node metastasis,bowel wall invasion and Dukes stage(rs=0.372,P =0.015;rs =0.372,P =0.015;rs = 0.429,P = 0.005).TIMP-1 was positively associated with Dukes stage, bowel wall invasion and regional lymph node metastasis (rs = 0.394, P = 0.010;rs= 0.382,P = 0.013rs = 0.382, P = 0.013 ).There was a positive corre-lafion between the expression of MMP-9 and TIMP-1 (rs=0.641, P <0.001).Conclusion MMP-9 and TIMP-1 may play a key role in colorectal carcinogenesis.Examination of MMP-9 and TIMP-1 expression may have an impor-tant significance for evaluating prognosis, predicting of invasion and metastasis and comprehensive therapy.
