CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women.
- Author:
Ledan WANG
1
;
Xiaosheng LU
;
Danhan WANG
;
Wanglei QU
;
Wenju LI
;
Xiaowen XU
;
Qiusui HUANG
;
Xueying HAN
;
Jieqiang LV
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: CYP19; endometriosis; infertility; single-nucleotide polymorphism
- MeSH: Adult; Aromatase/*genetics; Case-Control Studies; China; Endometriosis/complications/*genetics; Female; Genetic Predisposition to Disease; Humans; Infertility, Female/complications/*genetics; Middle Aged; *Polymorphism, Single Nucleotide
- From:Experimental & Molecular Medicine 2014;46(6):e103-
- CountryRepublic of Korea
- Language:English
- Abstract: An aromatase encoded by the CYP19 gene catalyzes the final step in the biosynthesis of estrogens, which is related to endometriosis development. To assess the association of CYP19 gene polymorphisms with the risks of endometriosis, chocolate cysts and endometriosis-related infertility, a case-control study was conducted in Chinese Han women by recruiting 225 healthy control females, 146 patients with endometriosis, 94 endometriosis women with chocolate cyst and 65 women with infertility resulting from endometriosis, as diagnosed by both pathological and laparoscopic findings. Individual genotypes at rs2236722:T>C, rs700518:A>G, rs10046:T>C and [TTTA]n polymorphisms were identified. Allelic and genotypic frequencies were compared between the control group and case groups by chi-square analysis. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined by logistic regression analysis to predict the association of CYP19 gene polymorphisms with the risk of endometriosis, the related chocolate cysts and infertility. The genotype distributions of the tested CYP19 gene polymorphisms were not significantly different between the healthy control group and the endometriosis/endometriosis with the chocolate cyst group. However, the CYP19 rs700518AA genotype was significantly associated with an increased risk of endometriosis-related infertility (55.4% in the infertility group vs 25.3% in the control group, P<0.001; OR (95% CI): 3.66 (2.06-6.50)) under the recessive form of the A allele. Therefore, we concluded that in Chinese Han females CYP19 gene polymorphisms are not associated with susceptibility to endometriosis or chocolate cysts, whereas CYP19 rs700518AA genotype confers genetic susceptibility to endometriosis-related infertility.
