The anti-inflammatory effect of Resveratrol on collagen-induced arthritis rats
10.3760/cma.j.issn.1007-7480.2009.02.015
- VernacularTitle:白藜芦醇对胶原诱导大鼠关节炎的抗炎作用研究
- Author:
Jinfeng DU
;
Fen LI
;
Jing TIAN
;
Xi XIE
;
Jinwei CHEN
;
Jiesheng GAO
- Publication Type:Journal Article
- Keywords:
Resveratrol;
Arthritis,collagen induced
- From:
Chinese Journal of Rheumatology
2009;13(2):123-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-inflammatory effect of Resveratrol on type Ⅱ collagen induced arthritis.Methods Collagen induced arthritis (CIA) animal model was established by subcutaneous injection of type Ⅱ collagen emulsified with incomplete and complete Freud's adjuvant to Wistar rats.Fortytwo rats were successfully induced and randomly divided into 7 groups:the experimental group (A),the leflunomide treatment group (B),the TGP treatment group (C),the methotrexate group (D),the low dose Resveratrol group (E),the medium dose Resveratral group (F) and high dose Resveratrol group (G) and the normal control group (H).Symptoms of arthritis were recorded and selalm levels of the anti-C Ⅱ antibody were detected by ELISA.Results For arthritis index.there was no significant difference between groups E and A,neither between groups C and F.The arthritis index was lower in group G than group C,but both of them were higher than groups B and D.② For serum anti-C Ⅱ antibody level,that of group A was higher than groups B,C,D,F and G.There was no difference between groups A and E,and groups C and F.That of Group G was lower than groups C and E.Conclusion High and medium dose of Resveratrol can relieve foot joints swelling in the CIA rats,but low dose does not have similar effect.The effect of medium dose of Resveratrol iS similar to TGP,but weaker than that of leflunomide.Resveratrol may conduct its anti-inflammatory effect via lowering the concentration of the anti-C Ⅱ antibody in the serum.
