Expression and significance of Annexin Ⅱ protein in ovarian adenocarcinoma

VernacularTitle:钙磷脂结合蛋白Ⅱ在卵巢腺癌中的表达及其意义
Author: Xin GE ; Zhongfu YUAN ; Daoming LI ; Huiqin SONG ; Xiaoguang GU
Publication Type:Journal Article
Keywords: Ovarian carcinoma; Annexin Ⅱ; immunohistochemistry
From: Clinical Medicine of China 2009;25(2):189-191
CountryChina
Language:Chinese
Abstract: Objective To explore the expression and significance of Annexin Ⅱ protein in ovarian adenocar-einoma.Methods The expressions of Annexin Ⅱ protein were detected in 48 cases of ovarian adenocarcinoma and 10 cases of ovarian adenoma by SP immunohistochemistry.Results The positive rates of expression of Annexin Ⅱprotein in ovarian adenoma were 50.00% (5/10), and were 81.25% (39/48) in ovarian adenocareinoma (χ2 =4.414, P <0.05), in well and moderately-differentiated, poorly differentiated ovarian serous adenocarcinoma were 93.33% (14/15) and 78.95% (15/19) respectively (χ2 = 1.383 ,P0.05 ), and on the Ⅰ and Ⅱ stage, Ⅲ and Ⅳ stage of ovarian serous adenocarcinoma were 60.00% (6/10) and 95.83% ( 23/24 ) respectively (χ2=7.226, P <0.05).The positive rate in the group of ovarian serous adenocarcinoma with lymph node metastasis was 90.00% (27/30), while 50.00% (2/4) in the group without lymph node metastasis (χ2=4.502, P<0.05).Conclusion The positive expression of Annexin Ⅱ protein may be correlated with the carcinogenesis, development and lymph node metastasis of ovarian serous adenocarcinoma.