Aspergillosis infection after orthotopic liver transplantation
- VernacularTitle:原位肝移植术后并发曲霉菌感染的诊断和治疗
- Author:
Yi MA
;
Xiaoshun HE
;
Xiaofeng ZHU
;
Guodong WANG
;
Dongping WANG
;
Weiqiang JU
;
Linwei WU
;
Anbin HU
;
Qiang TAI
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Postoperative complications;
Aspergillus;
Infection
- From:
Chinese Journal of General Surgery
2008;23(7):493-495
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnosis,and management of aspergillosis infection in orthotopic liver transplant recipients.Methods The clinical data of 776 cases of orthotopic liver transplantation patients from 2000 to 2006 were collected and analyzed retrospectively.Results Aspergillosis infection occurred in 13 patients(1.68%),among those there were pulmonary aspergillus infection in 7 cases,hepatic aspergillus infection in 2,cerebral aspergillosis in one and multi-organ aspergillosis in 3.Liposomal amphotericin B was the main therapy especially for cases at early stage.7 patients died of aspergillosis and the aspergillosis-related mortality was 53.8%.Conclusion Early diagnosis and management remain the key for the prevention and cure for aspergillus infection and decreasing mortality.The use of anti-fungal therapy should follow the principle of eliminating the local infection,adjusting immunosuppressive regimen and use of sensitive anti-fungal drugs.Anti-fungal drugs should be started early,with sufficient dosage and long-term.
