Acute renal failure in acute liver failure patients undergoing liver transplantation
- VernacularTitle:急性肝功能衰竭患者肝移植术后急性肾功能衰竭的病因分析及综合治疗
- Author:
Tonghai XING
;
Zhihai PENG
;
Zheng ZHANG
;
Qinjun XU
;
Guoqing CHEN
;
Junmin XU
;
Lin ZHONG
;
Xing SUN
- Publication Type:Journal Article
- Keywords:
Live transplantation;
Liver failure,acute;
Kidney failure,acute;
Continuous renal replacement therapy
- From:
Chinese Journal of General Surgery
2008;23(7):496-499
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causes of acute renal failure(ARF)after orthtopic liver transplantation(OLT)in patients of acute liver failure(ALF)and the effects of systemic therapy based on continuous renal replacement(CRRT).Methods Clinical data of 412 patients who underwent liver transplantations between January 2001 and June 2006 were analyzed retrospectively (all the cases were followed up to June 2007).According to UNOS grading scale,54 patients were of acute liver failure(UNOS 1 and 2A).Posttransplant ARF developing in 17 cases underwent a systemic therapy based on CRRT as well as anti-rejection,anti-infection and nutrition support.The perioperative courses,complications,causes of death and follow up results were analyzed.Results There were no severe complications during CRRT.Perioperative mortality was 5.4%and 58.8%in patients without ARF and those with ARF respectively.the rate of complications was 35.1%vs 100%.1 year survival rate Was 89.2% vs 41.2%.3 year survival rate was 81.1% vs 41.2%.Condusions The effect of surgery mainly depends on the function of liver and other vital organs.The ALF recipients suffered from a high perioperative mortality,especially those with posttransplant ARL.The systemic therapy based on CRRT benefits patients with postoperative ARF.
