Single nucleotide polymorphism of estrogen metabolizing genes CYP17、CYP19 and breast cancer susceptibility
- VernacularTitle:雌激素代谢酶CYP17、CYP19单核苷多态性与乳腺癌易感性的相关性分析
- Author:
Wei XIE
;
Maohui FENG
;
Fubing WANG
;
Jiakuan CHEN
;
Tiantian CHENG
;
Mingbo HU
;
Chunguang LI
;
Yunfeng ZHOU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Disease susceptibility;
Polymorphism,single nucleotide
- From:
Chinese Journal of General Surgery
2008;23(7):540-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between single nucleotide polymorphism in estrogen metabolizing genes CYP17、CYP19 and breast cancer susceptibility.Methods A case-control study was performed.PCR-base restriction fragment length polymorphism(PCR-RFLP)and short tandem repeat polymorphism(STRP)assay were used to detect the single nucleotide polymorphism of CYP17、CYP19 in 213 breast cancer cases and 430 matched controls.Resuits CYP17 A2/A2 genotype was found in 6.7%of breast cancer cases,which was significantly higher(P＜0.05)than that in controls(2.4%);the frequency of A2 allele of CYP17 was 16.2%in breast cancer cases,which was significantly higher(P＜0.05)than that in controls(10.6%).There Was alSO significant difference in the frequency of(TTTA)10allele of CYP19 which was 12.4%in breast cancer cases and 8.2%in controls(P=0.02).Conclusions The allele of CYP17 A2 and CYP19(TTTA)10 and CYP17 A2/A2 genotype were positively associated with the susceptibility of breast cancer.
